Saeid Saghahazrati; Seyed Abdulmajid Ayatollahi; Farzad Kobarfard; Bagher Minaei
Volume 21, Issue 2 , February 2019, , Pages 1-9
Abstract
Background: Although Matricaria chamomilla L. oil has been shown to contribute to the differentiation of mesenchymal stem cells(MSCs) into insulin-producing cells, the molecular mechanisms underlying its effect in the treatment of Type 1 Diabetes mellitus(T1DM) is still not available.Objectives: The ...
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Background: Although Matricaria chamomilla L. oil has been shown to contribute to the differentiation of mesenchymal stem cells(MSCs) into insulin-producing cells, the molecular mechanisms underlying its effect in the treatment of Type 1 Diabetes mellitus(T1DM) is still not available.Objectives: The purpose of this study was to evaluate the effect of cultured MSCs on the surface of electrospun Poly-L-Lactide acid(PLLA) scaffolds coated with Matricaria chamomilla L. oil in treatment of T1DM and clarify its possible mechanisms.Methods: The current experimental study was performed using a total number of 36 male New Zealand white rabbits in the Experi-mental Animal Unit of Shahid Beheshti University of Medical Sciences Tehran, Iran, in 2018. A rabbit model of T1DM was establishedthrough a single intraperitoneal injection of streptozotocin (STZ) (80 mg/kg body weight)-1 dissolved in 0.2 mL of normal saline.For 21 days after implantation of cultured MSCs on the surface of electrospun PLLA scaffolds coated with Matricaria chamomilla L. oil,blood glucose levels, plasma insulin levels, plasma and pancreatic glucagon-like peptide 1 (GLP-1) were evaluated.Results: The STZ-treated rabbits exhibited decreased levels of blood glucose (P < 0.01 vs. other groups except control), increasedlevels of plasma insulin (P < 0.01 vs. other groups except control), plasma and pancreatic GLP-1 (P < 0.001 vs. control, and P < 0.05vs. other groups except control) at 21 days after implantation of cultured MSCs on the surface of electrospun PLLA scaffolds coatedwith Matricaria chamomilla L. oil.Conclusions: Collectively, our finding showed the presence of Matricaria chamomilla L. oil might improve survival and differentia-tion MSCs in insulin producing cells that can be attributed to antioxidant properties of its bioactive compounds.
Hosein Delavar Kasmaei; Zahra Ghorbanifar; Farid Zayeri; Bagher Minaei; Seyed Hamid Kamali; Hossein Rezaeizadeh; Gholamreza Amin; Ali Ghobadi; Zohreh Mirzaei
Volume 18, Issue 1 , 2018, Pages 1-7
Abstract
Background: Migraine is one of the most common and debilitating neurological problems. Although numerous preventive drugs are used to treat migraine, their complications are unavoidable. Application of herbal medicine, especially well-known medicinal plants, to treatment of chronic diseases, like migraine, ...
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Background: Migraine is one of the most common and debilitating neurological problems. Although numerous preventive drugs are used to treat migraine, their complications are unavoidable. Application of herbal medicine, especially well-known medicinal plants, to treatment of chronic diseases, like migraine, could be effective. Coriandrum sativum L. (C. sativum) fruit is one of the most commonly prescribed herbs in Persian medicine, which has been used to treat headache. Objectives: This study was designed to evaluate the effects of C. sativum syrup on duration, severity and frequency of migraine. Patients and Methods: A total of 68 migraineurs, who had the eligibility criteria, according to international headache society diagnostic criteria, were randomly assigned to intervention group (n = 34) or control group (n = 34). In addition to 500 mg of sodium valproate per day, in intervention group, they received 15 mL of Coriander fruit syrup and 15 mL of placebo syrup, in control group, three times a day, during a month. The subjects were followed for clinical efficacy at weeks 1, 2, 3 and 4. The number of migraine attacks per week, as well asthe duration and severity of attacks, were evaluated. Results: Of 68 patients randomized, 66 were included in analysis. The generalized estimating equations analysis showed that the Coriander fruit syrup decreased duration, severity and frequency of migraine, in the intervention group (P < 0.001). To be more precise, the mean migraine duration, severity and frequency, in the intervention group, were 5.7 hours, 3.65 units and about 50% less than control group, respectively. Conclusions: Results of this study showed that C. sativum fruit is efficient in reduction of the duration and frequency of migraine attacks and in diminishing pain degree.
